NEWS & MEDIA

Stem cells, cancer and “bad luck”

Bilbao, Spain - January 16, 2015

Just a few weeks ago a paper by Tomasetti and Vogelstein describing a mathematical model that correlates cancer incidence with the number of stem cell divisions in a plethora of human tissues was published in Science. This parameter is related to the cell replication activity of a particular tissue, ie, the cell turnover rate in that tissue, as some tissues renew their cells more slowly than others (compare brain tissue to intestinal epithelium). For about 2/3 of the tumors explored...
In this article the link between lipid metabolisms and self renewal in cancer stem cells is described, for the first time, through chemical inhibition of Acetyl-CoA Carboxilase (ACACA), derived from our collaboration with Dr. Javier Menendez’s group at ICO-Girona.
Back to top